We are beginning to see our earth as a whole, living, breathing organism, an entity, a being unto itself. It breathes. It has a heartbeat. It takes care of its children. It provides everything here that we could possibly need. It’s totally balanced. If you spend a day in the forest or somewhere in nature, you can see how all the systems on the planet work perfectly. It’s set up to live out its existence in absolute, perfect equilibrium and harmony.
So here we are, great mankind who knows so much, and we are doing our very best to destroy the planet by disrupting this balance and harmony. Our greed gets in the way to an enormous extent. We think we know best, and through ignorance and greed we are destroying the living, breathing organism of which we are a part. If we destroy earth, where are we going to live?
I often hear people say that they alone cannot make a difference and I have not always had the correct reply for that until recently and then this arrived in my inbox from Louise Hay and she always did such a good job in explaining basic concepts that are easy for everyone to grasp.
What you do, think and believe affects the outcome of your life and impacts everyone. It is time for us to reconnect with our soul and thus feel and know our connection to everything on earth and to our beautiful mother earth.
Read these words and start doing something today to help us all.....
"I know people become overwhelmed by the problems we are encountering now. It seems that just one person doing something will not affect anything in the entire scheme of things. But that is not so. If everyone did a little it would wind up being a lot. You may not be able to see the effects right in front of you, but believe me, Mother Earth feels it collectively.
Let’s be willing to see where can make small adjustments for the sake of the environment. Even if all you do is buy a cloth shopping bag, or turn the water tap off while you brush your teeth, you have contributed a great deal by doing it.
For the Highest Good of All
You can take this time to apply your personal growth methods to the entire planet. If you just do things for the planet and not for yourself, then you’re not in balance. If you only work for yourself and stop there, then that’s not balanced either.
So let’s see how we can begin to balance ourselves and the environment. We know that our thoughts shape and create our lives. We don’t always live the philosophy totally; nonetheless, we’ve accepted the basic premise. If we want to change the greater world around us, we need to change our thinking about it, not viewing it as them and us.
If all the effort you put out into complaining about what’s wrong with the world is applied to positive affirmations and visualizations of the world, you could begin to turn things around. Remember, every time you use your mind, you are connecting to like-minded people. If you inflict judgment, criticism, and prejudice on others, you are connecting to all the other people who are doing the same. However, if you are meditating, visualizing peace, loving yourself, and loving the planet, you are connecting with these kinds of people. You could be at home, bed-ridden, and still help to heal the planet by the way you use your mind—by practicing inner peace. I heard Robert Schuller of the United Nations once say, “The human species needs to know that we deserve to have peace.” How true those words are.
Lazaris has a wonderful exercise that I would like to share with you. Pick a spot on the planet. It could be anywhere—very far away or just around the corner—some place on the planet that you would like to help heal. Envision that place as peaceful, with people well fed and clothed and living in safety and peace. Take a moment every day and envision it.
Put your love to work to help heal the planet. You are important. By sharing your love and all the magnificent gifts within, you will begin to change the energy on this beautiful, blue-green, fragile planet that we call our home.
And so it is!"
~ Louise Hay
Tuesday, December 18, 2018
Saturday, December 8, 2018
Radicle thoughts to accept??
Can you accept that you are not your body, you are not your emotions and you are not your ailments?
Can you also accept that you are energy from a single source that created all and how about, you are space, full of energy vibrating with limitless possibilities that turn into physical reality through the observation by your conscious mind.
Your body is the vehicle you use to express your true self, your divinity or your soul. Have you taken the time to get to know who you truly are. Have you taken the time to connect with your soul, or are you too busy running around benefiting your ego and the desires of your body? I am not saying any of this is good to bad, I am merely offering alternative thoughts or ways to accept.
Can you become a conscious observer and observe your body and its expression, your emotions and what they reveal? Can you become the driver of your vehicle and control/master the energy with which your driver drives you?
Let’s take a step back...If you are not your body, your emotions or your ailments, then who are you?
And can you use your mind/brain to change anything?
You are in charge of the thoughts and emotions that govern your life. You can chose how and what to be at any given moment, but we are ruled by our habits and our conditioning and thus we allow our thoughts, emotions and habits to run/drive us, instead of us choosing or driving. We must be diligent in our awareness of what thoughts and emotions are driving our experiences and if we are not loving our experiences then we may need to chose differently. Take your power back and start using your body and brain instead of it using you.
Take back your brain!
Wednesday, November 21, 2018
Fluoride...get it out of your system.
Prenatal Fluoride Exposure Linked to ADHD in Kids
Prenatal exposure to higher levels of fluoride not only impairs cognitive development but also significantly increases the incidence of attention-deficit/hyperactivity disorder (ADHD) in children, new research shows.
"Our current study suggests that fluoride not only interferes with overall IQ or overall cognitive development but may also contribute to symptoms of ADHD," lead investigator Morteza Bashash, PhD, Dalla Lana School of Public Health, University of Toronto, Canada, told Medscape Medical News.
This isn't the first study linking fluoride to childhood ADHD or cognitive impairment. But, said Bashash, it is the first to find an increased incidence of ADHD with prenatal fluoride exposure.
"This work builds off of previous research I and my team published on this population demonstrating that higher levels of urine fluoride during pregnancy are associated with lower scores on tests of cognition and IQ in these school-age children," he said.
The study was published online October 10, 2018 in Environment International.
Dose-Dependent Relationship
Previous animal studies as well as clinical studies have raised concerns over potential effects of fluoride exposure on neurobehavioral development, such as lower IQ and attention deficits, the investigators note.
To examine the association between prenatal exposure and symptoms associated with ADHD, the researchers analyzed data on 213 mother-child pairs from the Early Life Exposures to Environmental Toxicants (ELEMENT) birth cohort study. The study recruited pregnant women from 1994 to 2005 and continues to follow these women and children.
The research team used maternal urinary samples and child assessments of ADHD-like behaviors at ages 6 to 12 years.
They measured urinary fluoride levels adjusted for creatinine (MUFcr) in spot urine samples collected during pregnancy.
Child assessments consisted of both the Conners' Rating Scales–Revised (CRS-R), which was completed by mothers, and the Conners' Continuous Performance Test (CPT-II), which was administered to the children.
Data were adjusted for factors known to affect neurodevelopment, including lead exposure, smoking history, gestational age at birth, maternal marital status, age at delivery, and socioeconomic status.
The investigators found that the mean MUFcr was 0.85 mg/L (SD = 0.33). The difference between the first and third quartiles, or interquartile range (IQR), was 0.46 mg/L.
Using gamma regression in multivariable adjusted models, the researchers found that a 0.5-mg/L higher MUFcr (about one IQR higher) corresponded with significantly higher scores on the CRS-R for DSM-IV Inattention (2.84 points; 95% confidence interval [CI], 0.84 - 4.84) and DSM-IV ADHD Total Index (2.38 points; 95% CI, 0.42 - 4.34).
Participants also scored higher on the symptom scales, including the Cognitive Problems and Inattention (2.54 points' 95% CI, 0.44 - 4.63) and the ADHD Index (2.47 points; 95% CI, 0.43 - 4.50).
"We observed a positive association between higher prenatal fluoride exposure and more behavioral symptoms of inattention, which provide further evidence suggesting neurotoxicity of early-life exposure to fluoride," said Bashash.
The investigators found no significant associations with outcomes on the CPT-II or on symptom scales assessing hyperactivity.
Sources of Fluoride
In addition to water fluoridation, fluoride is also added to dental products, and a range of foods contain it in varying quantities. One consequence of excess fluoride consumption is dental fluorosis, discoloration or pitting of teeth.
The Centers of Disease Control and Prevention (CDC) notes that from 1999 to 2004, about 33% of 6- to 11-year-olds had experienced some form of dental fluorosis.
The CDC has suggested measures to protect children.It has recommended that families with children younger than 8 years consider using alternate sources of drinking water or, if they live in an area where fluoride levels are higher than 2 ppm, filtering their water.
"Our findings, combined with evidence from other studies, reinforce the need for additional research on potential adverse effects of fluoride, particularly in pregnant women and children, and to ensure that the benefits of population-level fluoride supplementation outweigh any potential risks," said Bashash.
"Early-life exposures can play a critical role in disease susceptibility later in life, with increasing recognition of the link between disturbance of central nervous system development and neuropsychiatric and neurological disorders later in life," he added.
For the past 50 years, the medical establishment has claimed that fluoride is safe and effective; should the official position on fluoridation change?
"I do not believe our study alone can be used to answer this question," said Bashash.
More Research Needed
Commenting on the findings for Medscape Medical News, Alex Dimitriu, MD, who has board certification in psychiatry and sleep medicine and is founder of Menlo Park Psychiatry and Sleep Medicine,said it's worth noting that many mental health problems, ranging from depression to dementia and likely including ADHD, may be a consequence of numerous factors that together result in illness.
Dimitriu, who was not involved in this research, said that although the researchers may have identified one of many environmental factors that contribute to ADHD, he would like to see their findings replicated in a larger study "before taking a general position of advising against fluoridated water or products.
"Fluoridation is not all bad, and indeed there are health benefits, dental at least, which we benefit from. But if it's associated with increased ADHD, some pregnant mothers may wish to avoid fluoridated products, including toothpaste," said Dimitriu.
"Genetics," he said, "also play a role in ADHD, and numerous twin adoption studies support a strong genetic role. Sleep is also a major player. Any child with ADHD should be screened for sleep apnea and dentition. I cannot emphasize enough how many 'cures' I've seen for childhood ADHD which resulted from correcting sleep," Dimitriu said
The study was funded by the National Institute of Environmental Health Sciences, which is part of the National Institutes of Health. The study authors and Dr Dimitriu report no relevant financial relationships.
Environ Int. Published online October 10, 2018.
How long must we sit with our emotions?
How Long |
When we take the time to sit with our emotions fully, it will become apparent that the emotion was a catalyst for much needed healing.
Usually, if we allow ourselves to feel our emotions fully when they come up, they recede naturally, giving way to another and another. When an emotion haunts us, it is often because we are afraid of really feeling it. Emotions like despair and rage are powerful, and it is natural to want to hold them at bay. Certainly, we don't want to let them take us over so that we say or do things we later regret. When we are facing this kind of situation, it can be helpful to ask the spirit, "How long do I need to sit with these emotions, how long do I need to feel these emotions before they can pass?" If you ask sincerely and wait, an answer will come. Setting a time limit on your engagement with that difficult emotion may be just the technique you need to face it fully. When you have a sense of how much time you need to spend, set a timer. Sit down and make yourself available to the emotion that has been nagging you. All you have to do is feel it. Avoid getting attached to it or rejecting it. Simply let it ebb and flow within you. Emotions are by their nature cyclical, so you can trust that just as one reaches its apex it will pass. Each time you sit with its presence without either repressing or acting out, you will find that that difficult emotion was the catalyst for much needed emotional healing. |
Monday, November 19, 2018
Preserve muscle and bone mass with healthy weight loss.
Healthy Weight Loss Preserves Muscles and Bones | ||||
Weight loss, even a modest amount, leads to numerous health benefits for individuals with overweight or obesity. But pursuing weight loss without considering the science of whole body composition is a lopsided approach that can lead to unintended, negative outcomes. This is because weight loss is not strictly relegated to loss of adipose tissue but will also net lean muscle and bone mass losses if proper, targeted nutrition and physical activities are not included with intentionality in the weight loss approach.
Healthy Weight Loss Preserves Muscle and Bone Mass
by Bianca Garilli, ND
Globally, 39% of adults aged ≥18 years were classified as overweight and 13% obese in 2016, totaling a jaw-dropping 1.9 billion adults overall.1 With obesity rates soaring, tripling worldwide since 1975, most of the Earth’s population now lives in countries where overweight and obesity cause more morbidity and mortality than being underweight.1
Keeping pace with these gains in adiposity is the behemoth weight loss and weight management market, which consists of fitness centers, slimming centers, consulting services, online weight loss programs, and associated products.2 In the US alone, the weight loss and weight management market is expected to reach USD 246.51 billion by the year 2022, a sharp increase from 2017 when this number was USD 175.94 billion, representing a compound annual growth rate (CAGR) of 6.9%.2 Although North America has historically taken the lead on weight loss and maintenance expenditure, Europe is a close second, and Asia is expected to register the highest CAGR by 2022 due to their rising incidence of overweight, obesity, and related chronic illnesses.2
Weight loss leads to numerous health benefits for individuals with obesity or overweight, including improved glycemic indices and cardiovascular health, in addition to reduced inflammation and a lower risk of all-cause mortality.3-4 In fact, modest weight loss (e.g. losing 5-10% of body weight) has been shown to improve fasting glucose, triglycerides, and total cholesterol, while losing >10% of total body weight ameliorates the previously mentioned biomarkers in addition to reducing LDL cholesterol levels.3
Nonetheless, striving for “weight loss” as the primary goal without properly integrating the total concept of body composition into the equation is a lopsided approach that may lead to unintended, negative outcomes. This is because weight loss is not strictly relegated to loss of adipose tissue but will naturally, in fact, also net lean muscle and bone losses if proper nutrition and physical activities are not included with intentionality in the weight loss approach.
Weight loss and reduced muscle mass
Weight loss, without appropriate focus on maintenance of healthy lean body mass, can result in lower muscle mass and consequently, reduced muscle strength.5 Over time, reduced muscle mass and strength have been shown to be predictors of reduced mobility, slower walking speed, long-term risk of disability, and lower rates of survival.5-6 It is critical then, that a healthy weight loss program includes methods aimed at maintaining a healthy level of muscle mass and strength for each individual. Regular moderate-to-vigorous physical activity and an exercise regimen that includes strength training helps maintain and even improve muscle mass and strength by stimulating muscle protein synthesis in the body.7-8
Maintaining healthy muscle mass levels is also influenced by nutritional inputs when undergoing calorie-restrictive weight loss programs. Several studies have confirmed findings that elderly individuals with obesity lose less muscle mass with hypocaloric weight loss programs that include exercise and a diet higher in protein than the control group; one of these studies recommended 1.2 g of protein per kg body weight.8-9
Weight loss and reduced bone mass
A similar situation can be seen with concurrent weight and bone mass losses. In fact, many healthcare professionals are reluctant to recommend weight loss in the elderly or in frail individuals who are overweight for fear that the weight loss will also result in a bone mineral density (BMD) reduction. However, the relationship between weight loss and bone is much more nuanced.10-11
Weight loss is more likely to impact hip and lumbar spine BMD (hip > spine losses), but usually does not net total BMD loss.11 Furthermore, bone density is more closely linked to lean mass than total body and fat mass; in fact, moderate weight loss accompanied by an age- and condition-appropriate exercise approach, particularly including strength training and high impact loading activities, can mitigate BMD loss and even result in BMD gains.10 Interestingly, in a review of 32 randomized controlled trials, BMD effects varied with the weight loss approach – calorie restriction, calorie restriction + exercise training, or exercise training alone:11
Think ‘whole body’ when it comes to weight loss
Achieving and maintaining a healthy weight is a prudent goal associated with significant health gains. The caveat is that weight loss can occur in a multitude of ways – both healthy and unhealthy. It’s less about the number on the scale and much more about overall, strategic body composition changes. Current literature seems to indicate that healthy weight loss should include a structured, individualized dietary and exercise program complete with aerobic and strength training components and sufficient or higher (than the age- and gender-specific IOM RDAs) daily protein consumption. Programs including both aspects (exercise and nutrition) will support healthy muscle mass, muscle strength, and bone mineral density, which together encourage long-term mobility, strength, wellness, and survival.
Citations
Bianca Garilli, ND
Dr. Garilli is a former US Marine turned Naturopathic Doctor (ND). She works in private practice in Northern California as well as running a consulting company working with leaders in the natural and functional medicine world such as the Institute for Functional Medicine and Metagenics. She is passionate about optimizing health and wellness in individuals, families, companies and communities- one lifestyle change at a time. Dr. Garilli has been on staff at the University of California Irvine, Susan Samueli Center for Integrative Medicine and is faculty at Hawthorn University. She is the creator of the Veterans for Health Initiative and is the current President of the Children’s Heart Foundation, CA Chapter.
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Friday, November 16, 2018
Another reason to love lavender essential oil
Lavender's Antianxiety Effects Nothing to Sniff At
The scent of lavender has long been thought to have calming, antianxiety effects, but the biological mechanism behind this phenomenon has been something of a mystery — until now.
Researchers in Japan found that the vaporized lavender compound linalool triggers a relaxing effect by directly stimulating olfactory sensory neurons.
For linalool to be used clinically in humans, the mechanism of linalool's anxiolytic effects need to be established. Findings from a new study provide a "foundation towards clinical application of linalool odor for anxiety disorders," the investigators write.
The study was published online October 23, 2018 in Frontiers in Behavioral Neuroscience.
"We confirmed the anxiolytic effects of linalool odor in normal mice," the authors write. The effects were "triggered by olfactory input evoked by linalool odor. Absorption to blood flow is not necessary," study investigator Hideki Kashiwadani, PhD, from Kagoshima University, Japan, told Medscape Medical News.
Notably, there was no anxiolytic effect in anosmic mice, whose olfactory neurons had been destroyed. This confirmed that the calming effect seen in normal mice was triggered by olfactory signals generated by smelling the lavender compound.
Soothing Scents
The researchers say it is notable that the animals' movements did not become impaired after the animals smelled linalool. By contrast, benzodiazepines and linalool injections had effects on movement that were similar to those caused by alcohol.
Kashiwadani noted that the site of action of linalool had not been addressed in prior studies. It has been assumed that absorption into the bloodstream via the airway leads to direct effects on gamma-aminobutyric acid A (GABAA) receptors, which are also the target of benzodiazepines.
Kashiwadani and colleagues found that in normal mice that had been pretreated with flumazenil, there was no anxiolytic effect from smelling linalool. Flumazenil blocks benzodiazepine-responsive GABAA receptors.
"When combined, these results suggest that linalool does not act directly on GABAA receptors like benzodiazepines do but must activate them via olfactory neurons in the nose in order to produce its relaxing effects," Kashiwadani said in a news release.
The researchers note that the anxiolytic effects induced by the odor of linalool "may be applicable for preoperative patients because pretreatment with anxiolytics can alleviate preoperative stress and thus contribute to place patients under general anesthesia more smoothly. In addition, for patients who may have difficulties with oral or suppository administration of anxiolytics, such as infants, utilizing linalool odor to help reduce anxiety may be a convenient and promising alternative," they add.
Kashiwadani believes that linalool may have effects in humans that are similar to the effects seen in mice "because the olfactory system of humans has basically quite similar structure with that of mice," he told Medscape Medical News. He added, "in the near future, I'll undertake the human study."
The study was supported by the Japan Society for the Promotion of Science. The authors have disclosed no relevant financial relationships.
Front Behav Neurosci. Published online October 23, 2018.
Wednesday, November 14, 2018
Household chemicals and how they affect our kids....
Another reason to “Detoxify”, especially before pregnancy…
Common Household Chemicals Tied to Language Delays in Kids
~Joel Evans MD
Early prenatal exposure to phthalates — the synthetic chemicals commonly found in household items and personal care products — has been tied to language delays in children, new research shows.In the first study of its kind, the collaboration between investigators from the Icahn School of Medicine at Mount Sinai, New York City, and Karlstad University, Sweden, showed that the risk for language delay was as much as 30% greater in children whose mothers were exposed to twice the levels of dibutyl phthalate and butyl benzyl phthalate, two chemicals commonly found in such everyday items as cosmetics, plastic toys, and food."The bottom line here is that the phthalates that a mother is exposed to in early pregnancy can affect the development of the brain in her children, particularly in this area of language development," principal investigator Shanna Swan, PhD, professor of environmental and public health at the Icahn School of Medicine at Mount Sinai, told Medscape Medical News."Unfortunately, these results point to different phthalates than we've found to be bad actors in the past. We've previously observed negative associations with di-ethylhexyl phthalate, which is more commonly found in food. Now we have more phthalates to worry about," said Swan.The study was published online October 29, 2018 in JAMA Pediatrics. (JAMA Pediatr. Published online October 29, 2018. doi:10.1001/jamapediatrics.2018.3115)Onus on Regulators, Manufacturers
Phthalates — high-volume semivolatile synthetic chemicals that make plastic soft and flexible — are used in a variety of industrial products, including polyvinyl chloride flooring, food packaging, personal-care products, medical supplies, and even toys. Their chemical structure precludes them from leaching, which is why they are often found in indoor air, dust, food, and water.Global biomonitoring data show that most phthalate metabolites are ubiquitous in the urine of children and adults alike. It is also present in blood, breast milk, and amniotic fluid.Previous research in both animals and humans has demonstrated that phthalates are endocrine disruptors with antiandrogenic properties. Indeed, prenatal phthalate exposure has been associated with male genital defects. Moreover, studies found inverse associations between phthalate metabolite level in prenatal urine and subsequent child neurodevelopment, behavioral outcomes, mental and psychomotor development, and neurologic status.Given that language-development delays can affect academic achievement later in life, such delays serve as an important indicator of later neurodevelopmental impairment.With that in mind, the investigators sought to examine the association between metabolite phthalate level in first-trimester urine samples and subsequent language development in early childhood.The researchers used data from two independent pregnancy cohort studies for the analysis — the Swedish Environmental Longitudinal, Mother and Child, Asthma and Allergy study (SELMA; 963 pregnant women and their children) and the Infant Development and Environment Study (TIDES; 370 women and their children). The latter study was conducted in the United States.In both trials, phthalate levels were obtained from the women at their first prenatal visit (median, 10th week of pregnancy). After their children were born and had begun acquiring language, the women were asked how many words their children understood (at 30 months in SELMA and 37 months in TIDES) through use of a screening questionnaire. The questionnaire is routinely used in Sweden and was translated into English. Responses were categorized as <25 25="" 50="" and="" to="">50 words. Children who understood <50 as="" classified="" delay.="" having="" language="" span="" were="" words="">50>25>Both studies found that 10% of children used 50 words or fewer; 2.7% understood fewer than 25 words. Interestingly, language delay was more common among boys than girls in both studies.Raw analyses of the data demonstrated that metabolites of two chemicals — dibutyl phthalate and butyl benzyl phthalate — were statistically significantly associated with language delay.After adjusting for potential confounders, a doubling of prenatal exposure to these two metabolites increased the odds ratio of language delay by 25% to 40%. These adjusted findings were significant in the Swedish study but not in the American study. The researchers attribute this difference to the smaller sample size in the US study.The investigators note that the current study is one of the first to examine the association between early language development and first-trimester phthalate exposure. The findings have far-reaching implications, given the ubiquity of phthalates in modern society."Until there's some testing of chemicals before they're put into products, we're not going to get around this," Swan said. "I don't think consumers can do very much, because these things aren't labeled. You don't know what's in your furniture, and you certainly don't know which foods have phthalates in them."So the consumer is at a loss," Swan added. "It really is the responsibility of the regulators and the manufacturers."Exposure Difficult to Avoid
Commenting on the findings for Medscape Medical News, Susan Schantz, PhD, professor of toxicology and neuroscience at the University of Illinois in Urbana, who was not involved in the study, said the findings are very much needed."We did a review a couple of years back looking at environmental chemicals and language development, and I was shocked to see how little research there was on this really important aspect of neurodevelopment," said Schantz."Phthalates are present in many different consumer products," Schantz added. "So it's very hard to avoid exposure. I think studies like this are important because we need to start phasing phthalates out of products and find better, less toxic solutions.""I don't know what the answer is," Swan concluded, "but I know we'd be doing pregnant women and their children a service if we could keep some of these chemicals out of their bodies."The studies were supported by grants from the National Institute of Environmental Health Sciences, the Swedish Research Council Formas, and the County Council of Varmland, Sweden.
Dr. Evans - Joel M. Evans, MD, a board-certified OB/GYN and international lecturer, is the Director of The Center for Functional Medicine in Stamford, CT. His book on the holistic approach to pregnancy, The Whole Pregnancy Handbook, has received widespread critical acclaim and media attention. He is currently the Medical Director of the Association for Prenatal and Perinatal Psychology and Health. Dr. Evans is a Founding Diplomate of the American Board of Holistic Medicine and is recognized as the first physician in Connecticut to be Board Certified in both Integrative Medicine and Obstetrics and Gynecology.
He is a member of the senior faculty of two of the most recognized and prestigious teaching institutions in integrative medicine: The Institute for Functional Medicine and the Center for Mind/Body Medicine. He continues to serve as the “external lead” of the IFM Advanced Practice Module in Hormone Health since its inception in 2011. Dr. Evans also helped create a clinical study at Columbia University Medical Center on the use of the herb black cohosh in breast cancer, which was presented at the 2001 Annual Meeting of the American Society of Clinical Oncologists and later published in their journal.
Monday, November 12, 2018
What is health really?
I heard a really interesting podcast and it made me think....
Health isn't just about affordable healthcare or diet and exercise, it is about feeling safe, having a roof over your head and being able to afford food and your rent.
It is about being able to care for your family and being able to work and provide.
We are all responsible for shifting the focus from affordable healthcare to affordable housing, healthy food and safety for all. Being healthy depends on feeling safe and cared for and supported.
Many people out there do not feel supported or heard. There is so much discrimination and fear and hatred in our world and this is creating an overall energy of ill health.
Being healthy is also about your brain...thinking healthy thoughts and having healthy feelings. When you are struggling to survive, it's hard to have healthy feelings and healthy thoughts as you are constantly flooding your body with stress hormones and some are sinking deeper into depression. Deeper down the rabbit hole of being alone and scared.
When we spout out our political beliefs and continue to separate ourselves from each other we continue to spread the seeds of unhealthy energy.
When we keep hoarding our stuff and fight to protect it, we forget the fundamental truth, that none of the stuff will keep our bodies and minds healthy. A lack love and compassion for the world we live in and all it's inhabitants is UNHEALTHY.
Take a moment to put yourself in the shoes of those that have two jobs and still cannot afford to pay their rent or buy the basics things needed in life...shelter, food, warm clothes. (The ones you pass on the street and know nothing about, but still judge and sometimes condemn) Our humanity demands that we start realizing that we are all on this planet together and we are all capable of helping and supporting each other and demanding that our leaders start paying attention to the basic needs of its citizens. The basics that will improve their health and wellbeing.
What are you going to do today to improve the health and wellbeing of the people and planet you are a part of?
Health isn't just about affordable healthcare or diet and exercise, it is about feeling safe, having a roof over your head and being able to afford food and your rent.
It is about being able to care for your family and being able to work and provide.
We are all responsible for shifting the focus from affordable healthcare to affordable housing, healthy food and safety for all. Being healthy depends on feeling safe and cared for and supported.
Many people out there do not feel supported or heard. There is so much discrimination and fear and hatred in our world and this is creating an overall energy of ill health.
Being healthy is also about your brain...thinking healthy thoughts and having healthy feelings. When you are struggling to survive, it's hard to have healthy feelings and healthy thoughts as you are constantly flooding your body with stress hormones and some are sinking deeper into depression. Deeper down the rabbit hole of being alone and scared.
When we spout out our political beliefs and continue to separate ourselves from each other we continue to spread the seeds of unhealthy energy.
When we keep hoarding our stuff and fight to protect it, we forget the fundamental truth, that none of the stuff will keep our bodies and minds healthy. A lack love and compassion for the world we live in and all it's inhabitants is UNHEALTHY.
Take a moment to put yourself in the shoes of those that have two jobs and still cannot afford to pay their rent or buy the basics things needed in life...shelter, food, warm clothes. (The ones you pass on the street and know nothing about, but still judge and sometimes condemn) Our humanity demands that we start realizing that we are all on this planet together and we are all capable of helping and supporting each other and demanding that our leaders start paying attention to the basic needs of its citizens. The basics that will improve their health and wellbeing.
What are you going to do today to improve the health and wellbeing of the people and planet you are a part of?
Wednesday, October 31, 2018
Fish oils and Cardiovascular Disease.
Don't Give Up on Fish Oil for CVD Prevention Just Yet
Hello. I'm Dr Arefa Cassoobhoy, a primary care internist, Medscape advisor, and senior medical director for WebMD. Welcome to Medscape Morning Report, our 1-minute news story for primary care.
You'd be forgiven if you were skeptical that fish oil could have a practice-changing role in preventing major adverse cardiovascular events (MACE). The data have been, at best, conflicting.
But now, recent topline results from the REDUCE-IT trial (see attached below), suggest that high doses of at least one omega-3—EPA (eicosapentaenoic acid)—could resurrect faith in fish oil for cardiovascular health.
The global study involved more than 8000 patients whose LDL levels were controlled on a statin. They also had risk factors, including persistently high triglyceride levels, cardiovascular disease, or diabetes with another risk factor.
The patients received either 4 g of EPA daily or placebo. After about 5 years, the EPA group saw a 25% relative risk reduction in MACE. And the results were highly statistically significant. MACE included death, nonfatal myocardial infarction or stroke, coronary revascularization, or unstable angina requiring hospitalization.
It's thought that the higher dose of pure EPA used in this study is the reason that they saw a stronger effect from fish oil compared with previous studies. Look out for more information when the data are presented at the 2018 American Heart Association meeting.
REDUCE-IT: 25% Reduction in MACE With High-Dose EPA
High doses (4-g daily) of the omega-3 oil eicosapentaenoic acid (EPA) have shown a large benefit on cardiovascular events in the randomized, double-blind REDUCE-IT trial.
Top-line results of the trial were announced yesterday in a press release by the sponsor, Amarin, which manufactures the high-dose EPA product under the brand name Vascepa.
The study involved 8179 patients from 11 countries who were at elevated cardiovascular risk (had a previous cardiovascular event or diabetes with one additional risk factor) and had raised triglyceride levels. All participants, who were already taking a statin, were randomized to 4 g of the pure EPA product daily or placebo.
After a median follow-up of 4.9 years, there was an approximately 25% relative risk reduction in the primary endpoint of first occurrence of a major adverse cardiovascular event — any one of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or unstable angina requiring hospitalization — in the EPA group, which was highly significant (P < .001), the company reported.
There were also "robust demonstrations of efficacy across multiple secondary endpoints," the company's statement said.
In terms of safety, the high-dose EPA was said to be "well tolerated," with similar proportions of patients experiencing adverse events and serious adverse events in the active and placebo treatment groups.
More details of REDUCE-IT will be presented by principal investigator Deepak L. Bhatt, MD, Brigham and Women's Hospital, Boston, Massachusetts, at the American Heart Association (AHA) Scientific Sessions 2018 on November 10, 2018 in Chicago, Illinois.
During a company conference call, John Thero, president and chief executive officer of Amarin, referred to the benefit of the high-dose EPA as "huge" and "exceeding all expectations."
"The 25% relative risk reduction in major cardiovascular events seen with Vascepa is comparable to that seen with atorvastatin, one of the most successful drugs of all time," he said, "and the benefit of Vascepa was seen on top of statin therapy therefore is addressing an unmet medical need."
"Clearly, lowering low-density lipoprotein cholesterol (LDL-C) alone is not enough," he said. "That can give a relative risk reduction of 25% to 35%, but this leaves a residual risk of 65% to 75%. The additional 25% relative risk reduction seen in this study is the single most impressive advance for preventative cardiovascular drug therapy since the advent of the statins."
The product is also easy to use, taken orally, safe, and inexpensive compared with other branded cardiovascular drugs, Thero added, "and it now has the potential to be used in millions of patients on top of statin therapy for additional cardiovascular risk reduction.”
500 mg/dL. The company plans to apply to the US Food and Drug Administration for this new indication based on results of REDUCE-IT in early 2019.
In an interview with Medscape Medical News, REDUCE-IT investigator Christie Ballantyne, MD, Baylor College of Medicine, Houston, Texas, said it was very important to understand the patient population enrolled in the study.
He noted that "70% of patients were secondary prevention and 30% high-risk primary prevention (had diabetes and one additional risk factor). All patients had baseline triglycerides over 150 mg/dL on statin therapy. This is very different from other studies which did not include elevated triglycerides as an entry criterion.”
"It's hard to believe that in this era of precision medicine there has never been a study before specifically addressing whether the lowering of triglycerides is beneficial in patients with elevated levels," Ballantyne commented.
He also pointed out that the dose of EPA used was probably a key factor in the benefit seen. "We used a high dose (4-g daily) of EPA alone, whereas most previous studies of omega-3 oils (most recently in the ASCEND trial) have used much lower doses of mixed oils. The only prior study that used EPA alone at higher doses was the Japanese JELIS trial, which used 1.8-g daily and also showed benefit."
Ballantyne noted that the JELIS trial did not stipulate that patients had to have raised triglyceride levels but the most benefit was seen in those who did. "The REDUCE-IT trial confirms the results of the JELIS trial but REDUCE-IT has a more rigorous design and a different patient population."
Ballantyne was reluctant to speculate on the clinical implications of the results at the present time. "I will let the clinicians at the AHA meeting decide on the clinical relevance of the data when they see it for themselves in more detail."
But he did say that "the study was powered for a 15% relative risk reduction, and we achieved a 25% relative risk reduction. Whenever you exceed the benefit aimed for, you get excited by the results."
"I have been in this field for a long time and witnessed many failures of drugs aiming to reduce cardiovascular risk. It will be great to get these data out to the cardiology community at AHA."
Commenting for Medscape Medical News, Henry Ginsberg, MD, University of Columbia, New York City, who was not involved in the study, said the reported results are "fascinating and important."
"I really didn't think that fish oils would show such a strong effect. I was guessing they might achieve a 10% to 12% benefit at the most. So this is terrifically exciting," he said. "It will change practice."
He agreed that the dosage was probably a key issue. "Previous fish oil studies have mainly used doses of around 1 g daily of mixed omega-3 oils and have not shown benefits. This trial has used 4 g of pure EPA," he noted. "The JELIS trial used 1.8-g daily of EPA, which showed a 19% benefit and was significant for secondary prevention but not for primary prevention."
"The JELIS study did not stipulate raised triglycerides for entry and the drop in triglycerides was modest," he noted, "but a post-hoc analysis showed a greater benefit in those patients with raised triglycerides at baseline."
Although lowering triglycerides with high-dose EPA was the main focus of the REDUCE-IT trial, Ballantyne noted that high doses of EPA have been shown to have other beneficial effects.
"Previous studies have suggested that in addition to lowering triglycerides, EPA has a favorable effect on inflammation and several other markers of atherosclerosis," he said. "Basically we don't know the mechanism. It may be the reduction in triglycerides but it also appears to do lots of other good things."
Thero added, "We view the JELIS results as supportive for using EPA to benefit patients without raised triglycerides as well as those with raised triglycerides. It suggests that the benefits of EPA are not brought about by triglyceride reduction alone."
Ginsberg estimated that about 30% of the US population have triglyceride levels above 150 mg/dL. "This percentage would be higher in a secondary prevention population — possibly 40%," he said.
Another trial of high-dose omega-3 oils for cardiovascular event reduction is underway. The STRENGTH trial is using a combination EPA/docosahexaenoic acid product with a total of 4-g omega-3 oils daily in patients with triglycerides over 200 mg/dL. Results are due out next year.
"The REDUCE-IT trial has shown a strong result," lead investigator of the STRENGTH trial, Steve Nissen, MD, Cleveland Clinic, Ohio, commented to Medscape Medical News.
"I am not surprised that it was successful," Nissen said. "Prior studies used small dosages of fish oil (1 g) and studied a broad group of patients. Both REDUCE-IT and STRENGTH treated patients with high triglycerides with full doses (4 g)."
The authors have reported no relevant financial relationships.
Reference: "A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High Risk Patients With Hypertriglyceridemia and on Statin. The Primary Objective is to Evaluate the Effect of 4 g/Day AMR101 for Preventing the Occurrence of a First Major Cardiovascular Event. (REDUCE-IT)” - ClinicalTrials.gov Identifier: NCT01492361
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